MLB Betting Lines and Picks Today | Sept. 21

Published 8:13 pm Friday, September 20, 2024

Saturday’s MLB slate features the Arizona Diamondbacks playing the Milwaukee Brewers at American Family Field.

Before Saturday’s MLB games, here’s an in-depth look at the betting odds.

Place your bets on any MLB matchup at BetMGM. Sign up today using our link.

MLB Betting Info Today – Sept. 21

Pittsburgh Pirates (72-81) at Cincinnati Reds (74-80)

Betting Info & Picks

  • Moneyline Favorite: Reds -125
  • Moneyline Underdog: Pirates +105
  • Total: 8.5 Runs (-115 to go over, -105 to go under)
  • Prediction: Reds 6, Pirates 5
  • Moneyline Pick: Reds (-125) over the Pirates (+105)
  • Total Pick: Over 8.5 Runs

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: SportsNet PT
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 1:10 PM ET
  • Venue: Great American Ball Park
  • Location: Cincinnati, Ohio
  • Reds Starter: Rhett Lowder (1-2, 1.74 ERA)
  • Pirates Starter: Jared Jones (6-7, 3.85 ERA)

Washington Nationals (68-86) at Chicago Cubs (79-75)

Betting Info & Picks

  • Moneyline Favorite: Cubs -145
  • Moneyline Underdog: Nationals +120
  • Total: Runs ( to go over, to go under)
  • Prediction: Cubs 6, Nationals 4
  • Moneyline Pick: Cubs (-145) over the Nationals (+120)

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: MASN2
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 2:20 PM ET
  • Venue: Wrigley Field
  • Location: Chicago, Illinois
  • Cubs Starter: Kyle Hendricks (4-11, 6.25 ERA)
  • Nationals Starter: MacKenzie Gore (9-12, 4.17 ERA)

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Detroit Tigers (80-73) at Baltimore Orioles (85-68)

Betting Info & Picks

  • Moneyline Favorite: Orioles -120
  • Moneyline Underdog: Tigers +100
  • Total: 8.5 Runs (-105 to go over, -115 to go under)
  • Prediction: Orioles 6, Tigers 5
  • Moneyline Pick: Orioles (-120) over the Tigers (+100)
  • Total Pick: Over 8.5 Runs

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: BSDET
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 4:05 PM ET
  • Venue: Oriole Park at Camden Yards
  • Location: Baltimore, Maryland
  • Orioles Starter: Cade Povich (2-9, 5.74 ERA)
  • Tigers Starter: Reese Olson (4-8, 3.5 ERA)

Minnesota Twins (80-73) at Boston Red Sox (76-77)

Betting Info & Picks

  • Moneyline Favorite: Red Sox -135
  • Moneyline Underdog: Twins +110
  • Total: 8 Runs (-110 to go over, -110 to go under)
  • Prediction: Red Sox 6, Twins 5
  • Moneyline Pick: Red Sox (110) over the Twins (-135)
  • Total Pick: Over 8 Runs

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: BSN
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 4:10 PM ET
  • Venue: Fenway Park
  • Location: Boston, Massachusetts
  • Red Sox Starter: Kutter Crawford (8-15, 4.19 ERA)
  • Twins Starter: Pablo Lopez (15-8, 3.84 ERA)

Toronto Blue Jays (73-80) at Tampa Bay Rays (75-78)

Betting Info & Picks

  • Moneyline Favorite: Rays -140
  • Moneyline Underdog: Blue Jays +115
  • Total: 7.5 Runs (-125 to go over, -105 to go under)
  • Prediction: Rays 5, Blue Jays 4
  • Moneyline Pick: Rays (-140) over the Blue Jays (+115)
  • Total Pick: Over 7.5 Runs

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: BSSUN
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 4:10 PM ET
  • Venue: Tropicana Field
  • Location: St. Petersburg, Florida
  • Rays Starter: Taj Bradley (6-11, 4.39 ERA)
  • Blue Jays Starter: Yariel Rodriguez (1-6, 4.29 ERA)

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Philadelphia Phillies (91-62) at New York Mets (85-68)

Betting Info & Picks

  • Moneyline Favorite: Mets -115
  • Moneyline Underdog: Phillies -105
  • Total: 7.5 Runs (+100 to go over, -120 to go under)
  • Prediction: Mets 5, Phillies 4
  • Moneyline Pick: Mets (-115) over the Phillies (-105)
  • Total Pick: Over 7.5 Runs

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: SNY
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 4:10 PM ET
  • Venue: Citi Field
  • Location: Queens, New York
  • Mets Starter: Sean Manaea (11-5, 3.26 ERA)
  • Phillies Starter: Ranger Suárez (12-7, 3.13 ERA)

Atlanta Braves (83-70) at Miami Marlins (56-97)

Betting Info & Picks

  • Moneyline Favorite: Braves
  • Moneyline Underdog: Marlins
  • Total: Runs ( to go over, to go under)
  • Prediction: Braves 5, Marlins 4
  • Moneyline Pick: Braves () over the Marlins ()

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: BSFL
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 4:10 PM ET
  • Venue: LoanDepot park
  • Location: Miami, Florida
  • Marlins Starter: Adam Oller (1-4, 5.4 ERA)
  • Braves Starter: Max Fried (9-10, 3.49 ERA)

San Francisco Giants (74-79) at Kansas City Royals (82-71)

Betting Info & Picks

  • Moneyline Favorite: Royals -150
  • Moneyline Underdog: Giants +125
  • Total: 8.5 Runs (-110 to go over, -110 to go under)
  • Prediction: Royals 5, Giants 4
  • Moneyline Pick: Royals (-150) over the Giants (+125)
  • Total Pick: Over 8.5 Runs

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: BSKC
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 5:10 PM ET
  • Venue: Kauffman Stadium
  • Location: Kansas City, Missouri
  • Royals Starter: Brady Singer (9-11, 3.53 ERA)
  • Giants Starter: Landen Roupp (0-1, 3.02 ERA)

Seattle Mariners (78-75) at Texas Rangers (73-80)

Betting Info & Picks

  • Moneyline Favorite: Rangers -145
  • Moneyline Underdog: Mariners +120
  • Total: 7.5 Runs (-125 to go over, -105 to go under)
  • Prediction: Rangers 5, Mariners 4
  • Moneyline Pick: Rangers (-145) over the Mariners (+120)
  • Total Pick: Over 7.5 Runs

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: ROOT Sports NW
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 7:05 PM ET
  • Venue: Globe Life Field
  • Location: Arlington, Texas
  • Rangers Starter: Max Scherzer (2-4, 3.95 ERA)
  • Mariners Starter: Emerson Hancock (3-4, 4.83 ERA)

Arizona Diamondbacks (85-68) at Milwaukee Brewers (88-65)

Betting Info & Picks

  • Moneyline Favorite: Brewers -115
  • Moneyline Underdog: Diamondbacks -105
  • Total: 8.5 Runs (+100 to go over, -120 to go under)
  • Prediction: Brewers 5, Diamondbacks 4
  • Moneyline Pick: Brewers (-115) over the Diamondbacks (-105)
  • Total Pick: Over 8.5 Runs

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: ARID
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 7:10 PM ET
  • Venue: American Family Field
  • Location: Milwaukee, Wisconsin
  • Brewers Starter: Aaron Civale (7-8, 4.48 ERA)
  • Diamondbacks Starter: Merrill Kelly (4-0, 4 ERA)

Los Angeles Angels (62-91) at Houston Astros (83-70)

Betting Info & Picks

  • Moneyline Favorite: Astros -250
  • Moneyline Underdog: Angels +200
  • Total: 8 Runs (-105 to go over, -115 to go under)
  • Prediction: Astros 5, Angels 3
  • Moneyline Pick: Astros (-250) over the Angels (+200)
  • Total Pick: Under 8 Runs

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: SCHN
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 7:10 PM ET
  • Venue: Minute Maid Park
  • Location: Houston, Texas
  • Astros Starter: Ronel Blanco (11-6, 2.88 ERA)
  • Angels Starter: Reid Detmers (4-7, 6.05 ERA)

Cleveland Guardians (89-65) at St. Louis Cardinals (77-76)

Betting Info & Picks

  • Moneyline Favorite: Cardinals -140
  • Moneyline Underdog: Guardians +115
  • Total: 8 Runs (-115 to go over, -105 to go under)
  • Prediction: Cardinals 5, Guardians 4
  • Moneyline Pick: Cardinals (115) over the Guardians (-140)
  • Total Pick: Over 8 Runs

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: BSGL
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 7:15 PM ET
  • Venue: Busch Stadium
  • Location: St. Louis, Missouri
  • Cardinals Starter: Miles Mikolas (8-11, 5.49 ERA)
  • Guardians Starter: Matthew Boyd (2-1, 2.52 ERA)

Chicago White Sox (36-117) at San Diego Padres (87-66)

Betting Info & Picks

  • Moneyline Favorite: Padres -275
  • Moneyline Underdog: White Sox +220
  • Total: 8 Runs (-120 to go over, +100 to go under)
  • Prediction: Padres 6, White Sox 3
  • Moneyline Pick: Padres (-275) over the White Sox (+220)
  • Total Pick: Over 8 Runs

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: NBCS-CHI
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 8:40 PM ET
  • Venue: PETCO Park
  • Location: San Diego, California
  • Padres Starter: Martín Pérez (4-5, 4.36 ERA)
  • White Sox Starter: Chris Flexen (2-14, 5.09 ERA)

New York Yankees (89-64) at Oakland Athletics (67-86)

Betting Info & Picks

  • Moneyline Favorite: Yankees -185
  • Moneyline Underdog: Athletics +150
  • Total: 8 Runs (+100 to go over, -120 to go under)
  • Prediction: Yankees 5, Athletics 4
  • Moneyline Pick: Yankees (-185) over the Athletics (+150)
  • Total Pick: Over 8 Runs

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: YES
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 9:07 PM ET
  • Venue: Oakland-Alameda County Coliseum
  • Location: Oakland, California
  • Athletics Starter: JP Sears (11-11, 4.24 ERA)
  • Yankees Starter: Carlos Rodón (15-9, 4.12 ERA)

Colorado Rockies (59-94) at Los Angeles Dodgers (91-62)

Betting Info & Picks

  • Moneyline Favorite: Dodgers -275
  • Moneyline Underdog: Rockies +220
  • Total: 8.5 Runs (-115 to go over, -105 to go under)
  • Prediction: Dodgers 5, Rockies 4
  • Moneyline Pick: Dodgers (-275) over the Rockies (+220)
  • Total Pick: Over 8.5 Runs

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: SportsNet LA
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 9:10 PM ET
  • Venue: Dodger Stadium
  • Location: Los Angeles, California
  • Dodgers Starter: Walker Buehler (1-5, 5.54 ERA)
  • Rockies Starter: Cal Quantrill (8-10, 4.68 ERA)

Catch MLB action all season long on Fubo.